Adenosine Receptor Antagonism By Theophylline In Theo Asthalin Forte: A Key Mechanism

Theophylline Anhydrous 200 mg in Theo Asthalin Forte 4 mg+200 mg exerts bronchodilatory effects through adenosine receptor antagonism—a mechanism distinct from Salbutamol's beta-2 agonism. Adenosine, an endogenous purine nucleoside, activates A1 and A2B receptors on airway smooth muscle and mast cells, promoting bronchoconstriction and histamine release. Theophylline competitively inhibits these receptors, blocking adenosine-mediated bronchospasm and reducing mast cell degranulation. This pathway is particularly relevant in exercise-induced bronchospasm, where adenosine levels rise acutely. The adenosine receptor antagonism also contributes to Theophylline's mild anti-inflammatory properties in chronic asthma management. Combined with Salbutamol's cAMP-mediated smooth muscle relaxation, this dual-receptor targeting provides a pharmacologically complementary approach to airway management. Manufactured by Cipla Ltd. Two tablets daily maximum. Physician consultation recommended.

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