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Responsible use of tramadol begins with understanding that it is a prescription medicine with opioid properties. It may provide relief for certain patients with moderate to moderately severe pain, but treatment decisions should be individualized. Tramadol affects pain pathways in the central nervous system through more than one mechanism, which contributes to its analgesic effects and also to some of its potential interactions. Patients should be aware of common effects such as dizziness, nausea, constipation, and drowsiness. More serious concerns include respiratory depression, dependence, misuse, seizures, and withdrawal. Tramadol may also interact with medicines that influence serotonin, including some antidepressants. Patients should provide their healthcare professional with an accurate list of medicines and supplements they take. If pain continues despite treatment, increasing the amount independently is not appropriate. A clinician can reassess the underlying condition and determine whether a different medication, non-drug therapy, or another pain-management strategy would be more suitable.
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